מגנזיום וטוראט- ההיפותיזה של בוני
מצטטת דברים שבוני כתבה בפורום טוראט בארה"ב ובו היא מפנה גם לתיאוריה שלה ובאתר שצרפתי תמצאי הסבר על התוספים Hello Sheila, Dr. Robbins, and everyone here on Latitudes forum, I was astounded and pleasantly surprised as I was doing some online research for a current study I am conducting with Robert DiSilvestro, PhD that is underway at Ohio State University into the nutritional aspects of TS. (The TSA has given permission to allow its members to participate in my study and participants in central Ohio are now being gathered!) I stumbled across a link to the CPhA (California Pharmacists Association) http://www.cpha.com/about/educ/ce/Feb03/0203ce.php that is a Feb 2003 continuing education article and test that teaches and references my hypothesis for a magnesium-rich supplement as an alternative treatment for TS: On page 18 under Other Treatments..." Magnesium deficiency has been proposed as a potential cause of tics. Grimaldi 5 presented a theory that a decrease in magnesium causes increases in the enzyme kynurenine, which confirms decreased levels of serotonin. Decreased magnesium also causes an increased activity of NMDA receptors because it can no longer plug the receptor, thus allowing calcium to enter the cell, facilitating activation. None of these theories have been tested in any trials or studies. Grimaldi recommends a trial that requires supplementation with 600 mg/day of magnesium orally (from taurine-chelated magnesium), vitamin B6, zinc, and other supplements. 5" (my note: kynurenine is not an enzyme, and the word "enzyme" should be deleted) Click on References http://www.cpha.com/about/educ/ce/Feb03/ref.php "5. Grimaldi BL. The Central Role of Magnesium Deficiency in Tourette's Syndrome: Causal Relationships Between Magnesium Deficiency, Altered Biochemical Pathways and Symptoms Relating to Tourette's Syndrome and Several Reported Comorbid Conditions. Medical Hypotheses 2002;58(1):47-60." http://www.ncbi.nih.gov/entrez/query.fcgi?...8&dopt=Abstract If you click on Table 5 http://www.cpha.com/about/educ/ce/Feb03/table5.php magnesium+supplements is listed under drug alternatives. It is even on the test!...(I can't cut and paste this pdf, so I will type it in - you can click on Take the Test)http://www.cpha.com/about/educ/ce/Feb03/feb03ceform.pdf "11. Which alternative therapy for TS has been proposed but not studied?" correct answer: "c. Magnesium replacement therapy" I haven't done a search to see if other similar highly esteemed medical organizations have also recognized my hypothesis as valid, but I am very encouraged! I look forward to helping to unlock the mysteries of TS through research. Due to my recently published hypothesis, my career has taken a turn towards graduate nutritional research at the Ohio State University where I am employed and also now a master's candidate in Nutrition. I look forward to helping to unlock the mysteries of TS through my research. In developing my hypothesis, I have come up with a list of supplements centered on magnesium metabolism and correction of magnesium deficient conditions that has helped many with TS which amazingly mirrors that found on Latitudes several years ago. Finally, for convenience to these supplement users, my loved one with TS, and those who have just now found out about them, I have formed a company, Bontech, http://bonniegr.com and developed an all-in-one supplement as an option instead of many different bottles at a similar price, but my ultimate goal and mission is to help those with TS through the highest quality nutritional research. As a magnesium-rich supplement, it can also be used by the general public for general good preventative health supplement and as a supplement for many proposed magnesium deficient conditions (in addition to inflammatory conditions in general). Warm regards, Bonnie Grimaldi, MT (ASCP), Master's candidate in Nutrition at The Ohio State University, managing member of Bontech Supplements, Ltd.
