המשך: צליאק ו-ADHD

[חגית35]

המשך: צליאק ו-ADHD

בהמשך לשאלה שנשאלה בנדון בעבר ראיתי היום איזכור מעניין בפורום MGH היום ל-ADHD בקשר לילדי צליאק והקשר לנטיה מוגברת למחלות נוירולוגיות ו-ADHD שדימו לב שהחוקרים הינם משלנו- נתנאל צלניק, מהטכניון בחיפה, והממצאים פורסמו לא מזמן: Nathanel Zelnik and his colleagues at Technion-Israel Institute of Technology in Haifa, Israel, examined 111 children who had been treated for the disease between 1977 and 2001. For comparison, the researchers also studied 211 healthy children. In the June /Pediatrics/, Zelnik's team identified neurological problems in 51 percent of the children with celiac disease and in only 20 percent of those without the disorder. The team also reports a new link between the disease and attention-deficit/hyperactivity disorder למי שמעוניין לקרוא

 

[חגית35]

דיאטה נטולת גלוטן, צליאק ו-ADHD

By Nathanel Zelnik, MD, Avi Pacht, MD, Raid Obeid, MD and Aaron Lerner, MD PEDIATRICS Vol. 113 No. 6 June 2004, pp. 1672-1676 Jun 22, 2004, 00:17 Objective. During the past 2 decades, celiac disease (CD) has been recognized as a multisystem autoimmune disorder. A growing body of distinct neurologic conditions such as cerebellar ataxia, epilepsy, myoclonic ataxia, chronic neuropathies, and dementia have been reported, mainly in middle-aged adults. There still are insufficient data on the association of CD with various neurologic disorders in children, adolescents, and young adults, including more common and "soft" neurologic conditions, such as headache, learning disorders, attention-deficit/hyperactivity disorder (ADHD), and tic disorders. The aim of the present study is to look for a broader spectrum of neurologic disorders in CD patients, most of them children or young adults. Methods. Patients with CD were asked to fill in a questionnaire regarding the presence of neurologic disorders or symptoms. Their medical charts were reviewed, and those who were reported as having neurologic manifestations underwent neurologic examination and brain imaging or electroencephalogram if required. Their neurologic data were compared with that of a control group matched for age and gender. Results. Patients with CD were more prone to develop neurologic disorders (51.4%) in comparison with control subjects (19.9%). These disorders include hypotonia, developmental delay, learning disorders and ADHD, headache, and cerebellar ataxia. Epileptic disorders were only marginally more common in CD. In contrast, no difference was found in the prevalence of tic disorders in both groups. Therapeutic benefit, with gluten-free diet, was demonstrated only in patients with transient infantile hypotonia and migraine headache. Conclusion. This study suggests that the variability of neurologic disorders that occur in CD is broader than previously reported and includes "softer" and more common neurologic disorders, such as chronic headache, developmental delay, hypotonia, and learning disorders or ADHD. Future longitudinal prospective studies might better define the full range of these neurologic disorders and their clinical response to a gluten-free diet. מי שילחץ בתוך הקישור על Full Text יוכל לקרוא קובץ מלא של מהלך המחקר בפורמט PDF

 

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