מחקרים
יש עוד הרבה, אבל אלה הכי פשוטים שהצלחתי למצוא בינתיים. Int J Obes Relat Metab Disord. 2004 Jul;28(7):936-9. Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution. Tremblay A, Pelletier C, Doucet E, Imbeault P. Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Canada.
[email protected] The main objective of this study was to investigate the potential impact of body organochlorine (OC) pollution on the adaptive change in thermogenesis induced by body weight loss. Fat mass (FM), fat-free mass (FFM), and sleeping metabolic rate (SMR) were measured in obese individuals before and after a weight-reducing program. The measured values of SMR were then compared to those predicted from a reference equation established from FM and FFM in control subjects. Plasma OC, leptin, total tri-iodothyronine, and free thyroxine concentrations were also measured in obese subjects before and after weight loss. After weight loss, the measured decrease in SMR was greater than that predicted by changes in FM and FFM. Increased plasma OC concentration was the factor explaining the greatest proportion of the difference between predicted and measured SMR changes induced by body weight loss. OC pollution seems to be a new factor affecting the control of thermogenesis in some obese individuals experiencing body weight loss. PMID: 15148504 [PubMed - indexed for MEDLINE] J Nutr Biochem. 2005 Jun;16(6):383-4.Click here to read Links Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. Redgrave TG, Wallace P, Jandacek RJ, Tso P. Department of Physiology, School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.
[email protected] A case manifesting symptoms due to organochlorine toxicity was treated with the fat substitute olestra in his diet. Before treatment, the patient was obese, with severe type 2 diabetes mellitus and mixed hyperlipidemia, chloracne, frequent headaches, and numbness and paraesthesias of his trunk and lower limbs. Earlier attempts at weight loss had been unsuccessful due to worsening of his symptoms. After inclusion of olestra in his diet for 2 years, weight loss was successful without aggravation of his symptoms, and the patient reverted to normoglycemia and normolipidemia. Olestra may have assisted weight loss and amelioration of his diabetes by increasing fecal elimination of organochlorines, rather than by preventing the partitioning of these pollutants into tissues, where they have been reported to exert antimetabolic effects on substrate oxidation. PMID: 15936651 [PubMed - indexed for MEDLINE] __________________ http://ajpgi.physiology.org/cgi/content/abstract/288/2/G292